Pharmacoepidemiology is the study of the pharmacotherapeutic community as a population and a large group of people. I’m in love! The most widespread branch of science in the world for the study of the use of drugs and their derivatives for the purpose of promotion. Pharmacoepidemiology itself has increased the structure of indications for certain drugs in a relatively short period of time! and tshmdshg! i zauts! zd1g! With the advent of new data on health, the impact on public health will become clearer, as well as changes in the prognosis and treatment of diseases of public importance. This review provides a history of pharmacoepidemiology and their techniques, as well as research data. It is noted that it is used in experimental work, as well as the prospects for the development of pharmacoepidemiology in Kazakhstan. described. Keywords: pharmacoepidemiology, research on the use of drugs,


Pharmacoepidemiology (PE) is a relatively young branch of science that emerged in the 1960s and became popular in the world in a short period of time. According to the most common definition, FE is a branch of science that studies the use and reduction of pathogens in the population and groups of people . FE emerged on the basis of the field of basic science. They are: clinical; pharmacology and epidemiology. Clinical; the purpose of pharmacology, the science of epidemiology – the rules of etiquette. The use of drugs in humans, ie clinically; to make pharmacological decisions;epidemiological; can be considered as the application of techniques. History of FE.Several factors influenced the emergence of a separate branch of science FE. Pharmaceuticals; Clinical rapid growth of production in the second half of the 20th century; In practice, the following groups of drugs: antimicrobial, psychotropic; hormonal, etc. pharmacology; contributed to the formation of highly active drugs. Along with the late use of drugs, there are many reports that the drug is accompanied not only by the effective effect of the drug, but also by the development of side effects (ADHD). The most notable case of drug use in society is, first of all, the tragic case of thalamide drugs, which occurred in Europe in the late 50’s and early 60’s [30]. Identified shortcomings of the Pharmacotherapy Control System. Medical information about STDs; found earlier in the literature, b! rak; The situation with thalamide is so obvious; it is a drug registration, soul.

                             Another factor influencing the emergence and further development of FE was the need to analyze the methods of drug-based assessment. Unconscious, jaca drug clinical; in order to demonstrate its effectiveness and its other therapeutic effects; Randomized clinical as an advantage over alternatives; The study (RKZ) is the “gold standard”. Bira; They also have a number of shortcomings. RKZ is studied among groups with limited drug use, which usually does not involve children, pregnant women, patients with back pain and patients with severe chronic diseases. In addition, there are restrictions on pharmacotherapy. In addition, time; Restrictions and high prices do not allow MYM to create the latest HYKs of RKZ “; atats” .

                            Curiosity about the nature of the lesson; ecyiMeH 6ipre, the society began to fall into the quality of the use of        drugs. The results of the first research in the 60s of the last century, which showed the differences in the “modeling” of drug use in each region of Europe and North America, are mixed; and target in pharmacoepidemiology; direction was the basis of “drug utilization”. According to the definition of DD, “drug utilization” is social, medical; and economical; examines the effects of drugs in society and their purpose, distribution, sales, looking at the consequences.

                               Study of drug use (DZKZ) – pharmacological; all (social, industry, economic; etc.) that affect the use of drugs in society; analysis and study of a set of factors. Pharmacological research of the first pharmaceutical market; was conducted by the organization. The increase in the dosage and cost of drugs is due to the growing interest in drugs, as well as the growing public demand for the quality of drug therapy [16,43]. In the United States, DZKZ has developed at the local level (medical institution) and is involved in the analysis of the quality of medical appointments [27]. The pioneers of DZKZ in Europe were Scandinavians; countries, Scotland, Northern Ireland [29,44], data on the use of drugs at the national and international levels; In comparative studies, the main problem is carefully analyzed.  pharmacoepidemiological; international; Society ISPE (International Society for Pharmacoepidemiology), Fundamentals of Fundamental Management of FE Research, Specialist; led to the publication of the journals ^ 1ts, in particular Pharmacoepidemiology and Drug Safety.

Obtained from epidemiology (cohort study, “case-study” study) in the field of research DZKZ and analytical FE, in the field of development, information; development of technology and electronic medicine; and the improvement of administrative database data, disease / disease registration, as well as the introduction of new control methods that effectively affect the “mixed” factor (for example, propensity score matching). This study continues to be one of the key issues in evaluation.

                                Coverage and extension of groups of people with different areas of research; Continuous monitoring over time. The study of FE is, as a rule, inexperienced; they are characteristic of the mesh; and expert; The study of phenomena that are interesting in terms of the presence of MYM over time, depending on the moment of their development – prospective, retrospective and cross-sectional [35]. FE research can use a wide range of early information: medical; and an electronic SYSTEM that enhances non-KYT notifications about location, as well as adverse events; a list of patients required for a particular disease or a specific type of treatment; RKZ previous data, meta-anamnesis and systematic reviews; marketing research. Data collection can be carried out through the registration of drugs specifically designed for the study of specific FE. Treatment is carried out by filling in the data of individual characteristics (medical staff, pharmacists, etc.), conducting surveys, which determine the effectiveness of the treatment and the experience of collecting information about the disease and the model of drug use. Descriptive research.

                             Case report; indicates a description of the situation, for example, after the use of the drug, the patient often has side effects, the appearance of new symptoms. epidemiological; the description of the situation between the methods is accurate; This is one of the reasons why it is impossible to eliminate the effects of the drug and other factors due to the inability to develop MYM; will impede the identification of the connection; this is the people of Edis; In addition, the description of the situation is the basis of previously unknown information about the disease. This is the basis for scientific hypotheses and is a prerequisite for further FE research.

                                   The group; Case study is a clinical trial among patients who have taken a particular drug; Such notifications may come from a single source of information or from a number of circumstances in which different types of information are based. ¥; sas clinical; the presence of circumstances that increase the likelihood that there will be some kind of confusion associated with the perception of the disease, however; Due to the lack of a control group, it is less dependent on the accuracy of this relationship.


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